Carries out his research and didactical activities in the area of Advanced Biomedical Signals Analysis at the Department of Electronics, Information and Bioengineering (DEIB). In previous years, at the same Politecnico, he has been i) Chairman of the Bachelor Track in Biomedical Engineering (1996-2000), ii) Head of the Department of Bioengineering (2000-2006), and iii) Chairman of the Programs of Biomedical Engineering (2010-2012).Emeritus Professor at the Politecnico in Milano where he carries out his research and didactical activities in the area of Advanced Biomedical Signals Analysis at the Department of Electronics, Information and Bioengineering (DEIB). In previous years, at the same Politecnico, he has been i) Chairman of the Bachelor Track in Biomedical Engineering (1996-2000), ii) Head of the Department of Bioengineering (2000-2006), and iii) Chairman of the Programs of Biomedical Engineering (2010-2012). His research activity is mainly dedicated to various aspects of biomedical signals, data processing and modeling related to the field of neurosciences as well as in cardiovascular and autonomic nervous system applications. More recently, he dedicated himself also to Biomedical Imaging, the Fusion of Biosignals with Medical Images, and Bioinformatics, i.e. the applications of modeling techniques and data processing to the strings of information contained in the DNA, RNA and in proteomics data. He is the Author of more than 700 indexed international scientific contributions. His h-Index is 79 (Google Scholar), with an overall number of citations of more than 56,000. He has coordinated or was involved in various research projects at national and international levels in various topics of Biomedical Engineering and Bioinformatics. The most recent ones funded by EU are: My-Heart, Heart Cycle, Psyche and Link. He spent over a year as a Visiting Professor at MIT and Harvard School of Public Health, Boston MA, USA, in the ‘80s, as well as a period of 4 months at the Department of Physics of the IST (Instituto Superior Tecnico), Technical University in Lisbon, Portugal, in 2008. Starting from 1995 he has been the organiser of 6 IEEE-EMBS International Summer Schools on Advanced Biomedical Signal Processing held in Siena and in Pavia, as well as of Biosignal Interpretation Conferences (BSI). In 2015 he has been the Conference Chair of the 37th Annual Conference of IEEE-EMBS in Milano (more than 3300 participants).

He is a Member of the Editorial Board of various journals in the Biomedical Engineering area: in particular, he is an Associate Editor of IEEE Transactions on Biomedical Engineering and Physiological Measurements and he is in the editorial board of Medical Engineering & Physics, Biomedical Signal Processing & Control, Medical and Biological Engineering & Computing, Annals of Non- Invasive Electrocardiology, Critical Reviews in Biomedical Engineering, etc.